diff --git a/infer/src/base/Config.ml b/infer/src/base/Config.ml
index d8a1d9509..8515d3913 100644
--- a/infer/src/base/Config.ml
+++ b/infer/src/base/Config.ml
@@ -641,11 +641,13 @@ and clang_frontend_action =
     "Specify whether the clang frontend should capture or lint or both."
     ~symbols:clang_frontend_action_symbols
 
-and clang_include_to_override =
-  CLOpt.mk_string_opt ~long:"clang-include-to-override" ~meta:"dir"
+and clang_include_to_override_regex =
+  CLOpt.mk_string_opt ~long:"clang-include-to-override-regex"
+    ~deprecated:["-clang-include-to-override"]
+    ~meta:"dir OCaml regex"
     "Use this option in the uncommon case where the normal compilation process overrides the \
-     location of internal compiler headers. This option should specify the path to those headers \
-     so that infer can use its own clang internal headers instead."
+     location of internal compiler headers. This option should specify regular expression with \
+     the path to those headers so that infer can use its own clang internal headers instead."
 
 and classpath =
   CLOpt.mk_string_opt ~long:"classpath"
@@ -1625,7 +1627,7 @@ and dump_duplicate_symbols = !dump_duplicate_symbols
 and checkers = !checkers
 and checkers_repeated_calls = !checkers_repeated_calls
 and clang_biniou_file = !clang_biniou_file
-and clang_include_to_override = !clang_include_to_override
+and clang_include_to_override_regex = !clang_include_to_override_regex
 and classpath = !classpath
 and cluster_cmdline = !cluster
 and compute_analytics = !compute_analytics
diff --git a/infer/src/base/Config.mli b/infer/src/base/Config.mli
index 4dc6eea09..65a6b0e33 100644
--- a/infer/src/base/Config.mli
+++ b/infer/src/base/Config.mli
@@ -197,7 +197,7 @@ val clang_biniou_file : string option
 val clang_frontend_action_string : string
 val clang_frontend_do_capture : bool
 val clang_frontend_do_lint : bool
-val clang_include_to_override : string option
+val clang_include_to_override_regex : string option
 val cluster_cmdline : string option
 val compute_analytics : bool
 val continue_capture : bool
diff --git a/infer/src/clang/ClangCommand.re b/infer/src/clang/ClangCommand.re
index 9d76c5332..13c947b22 100644
--- a/infer/src/clang/ClangCommand.re
+++ b/infer/src/clang/ClangCommand.re
@@ -81,6 +81,8 @@ let file_arg_cmd_sanitizer cmd => {
   {...cmd, argv: [Format.sprintf "@%s" file]}
 };
 
+let include_override_regex = Option.map f::Str.regexp Config.clang_include_to_override_regex;
+
 /* Work around various path or library issues occurring when one tries to substitute Apple's version
    of clang with a different version. Also mitigate version discrepancies in clang's
    fatal warnings. */
@@ -105,8 +107,8 @@ let clang_cc1_cmd_sanitizer cmd => {
     } else if (
       String.equal option "-isystem"
     ) {
-      switch Config.clang_include_to_override {
-      | Some to_replace when String.equal arg to_replace =>
+      switch include_override_regex {
+      | Some regexp when Str.string_match regexp arg 0 =>
         fcp_dir ^\/ "clang" ^\/ "install" ^\/ "lib" ^\/ "clang" ^\/ "4.0.0" ^\/ "include"
       | _ => arg
       }