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pt7b5kpz9 5 months ago
parent f9d426d660
commit 484763e239

@ -0,0 +1,334 @@
#include <iostream>
#include <string>
#include <algorithm>
#include <fstream>
#include <windows.h>
using namespace std;
#define INDEL_CHAR '-'
int MATCH = 1, DIS_MATCH = -1, INDEL = -3;
char choice1, choice2;
class ResUnit //一次双序列比对后的结果
{
public:
string str1; //原始序列1
string str2; //原始序列2
string res1; //结果序列1
string res2; //结果序列2
int score; //序列总得分,反映两个序列的相似程度
int tag; //禁止迭代多次
};
class SingleSeq //一个序列被整合后的样子
{
public:
string str; //一个序列的原始序列
string res; //一个序列被整合后的样子
};
struct BacktrackingUnit
{
int goUp; //是否向上回溯
int goLeftUp; //是否向左上回溯
int goLeft; //是否向左回溯
int score; //得分矩阵第(i, j)这个单元的分值
};
typedef struct BacktrackingUnit *unitLine;
struct SequenceUnit
{
string *str1; //匹配序列1
string *str2; //匹配序列2
int score;
};
int max3(int a, int b, int c)
{
return max(max(a, b), c);
}
int Compare(char a, char b)
{
if (a == b)
return MATCH;
else if (a == ' ' || b == ' ')
return INDEL;
return DIS_MATCH;
}
ResUnit traceback(unitLine **item, const int i, const int j, string str1,
string str2, string res1, string res2, int n, ResUnit resUnit)
{
unitLine temp = item[i][j];
if (resUnit.tag != 1)
{
if (!(i || j)) // 到矩阵单元(0, 0)才算结束,这代表初始的两个字符串的每个字符都被比对到了
{
resUnit.str1 = str1;
resUnit.str2 = str2;
resUnit.res1 = res1;
resUnit.res2 = res2;
resUnit.tag = 1;
return resUnit;
}
if (temp->goUp) // 向上回溯一格
{
res1 = str1[i - 1] + res1;
res2 = INDEL_CHAR + res2;
resUnit = traceback(item, i - 1, j, str1, str2, res1, res2, n + 1, resUnit);
}
if (temp->goLeftUp) // 向左上回溯一格
{
res1 = str1[i - 1] + res1;
res2 = str2[j - 1] + res2;
resUnit = traceback(item, i - 1, j - 1, str1, str2, res1, res2, n + 1, resUnit);
}
if (temp->goLeft) // 向左回溯一格
{
res1 = INDEL_CHAR + res1;
res2 = str2[j - 1] + res2;
resUnit = traceback(item, i, j - 1, str1, str2, res1, res2, n + 1, resUnit);
}
return resUnit;
}
return resUnit;
}
ResUnit NeedlemanWunch(string str1, string str2)
{
const int m = str1.length();
const int n = str2.length();
int m1, m2, m3, mm;
unitLine **unit;
// 初始化
if ((unit = (unitLine **)malloc(sizeof(unitLine *) * (m + 1))) == NULL)
exit(1);
for (int i = 0; i <= m; i++)
{
if ((unit[i] = (unitLine *)malloc(sizeof(unitLine) * (n + 1))) == NULL)
exit(1);
for (int j = 0; j <= n; j++)
{
if ((unit[i][j] = (unitLine)malloc(sizeof(struct BacktrackingUnit))) == NULL)
exit(1);
unit[i][j]->goUp = 0;
unit[i][j]->goLeftUp = 0;
unit[i][j]->goLeft = 0;
}
}
unit[0][0]->score = 0;
for (int i = 1; i <= m; i++)
{
unit[i][0]->score = INDEL * i;
unit[i][0]->goUp = 1;
}
for (int j = 1; j <= n; j++)
{
unit[0][j]->score = INDEL * j;
unit[0][j]->goLeft = 1;
}
for (int i = 1; i <= m; i++)
{
for (int j = 1; j <= n; j++)
{
m1 = unit[i - 1][j]->score + INDEL;
m2 = unit[i - 1][j - 1]->score + Compare(str1[i - 1], str2[j - 1]);
m3 = unit[i][j - 1]->score + INDEL;
mm = max3(m1, m2, m3);
unit[i][j]->score = mm;
if (m1 == mm)
unit[i][j]->goUp = 1;
if (m2 == mm)
unit[i][j]->goLeftUp = 1;
if (m3 == mm)
unit[i][j]->goLeft = 1;
}
}
ResUnit res;
res.tag = 0;
res = traceback(unit, m, n, str1, str2, "", "", 0, res);
res.score = unit[m][n]->score;
//释放内存
for (int i = 0; i <= m; i++)
{
for (int j = 0; j <= n; j++)
free(unit[i][j]);
free(unit[i]);
}
free(unit);
return res;
}
bool legal_string(string s)
{
for (unsigned i = 0; i < s.size(); i++)
if (s[i] != 'A' && s[i] != 'T' && s[i] != 'C' && s[i] != 'G')
return false;
return true;
}
void read(string &a, string &b)
{
if (!choice1 && !choice2)
{
while (true)
{
cout << "请选择:\n1.键盘读入\n2.文本读入\n";
cin >> choice1;
if (choice1 != '1' && choice1 != '2')
{
cout << "#请选择合法的选项!\n";
Sleep(1000);
}
else
break;
}
while (true)
{
cout << "请选择:\n1.输出到显示屏\n2.输出为文本\n";
cin >> choice2;
if (choice2 != '1' && choice2 != '2')
{
cout << "#请选择合法的选项!\n";
Sleep(1000);
}
else
break;
}
}
if (choice1 == '1')
{
while (true)
{
cout << "请输入需要比对的基因序列:\n序列一:";
cin >> a;
if (legal_string(a))
break;
else
{
cout << "#请输入合法的基因序列!\n";
Sleep(1000);
}
}
while (true)
{
cout << "序列二:";
cin >> b;
if (legal_string(b))
break;
else
{
cout << "#请输入合法的基因序列!\n";
Sleep(1000);
}
}
}
else
{
while (true)
{
char x;
cout << "文本输入完成请输入 1\n";
while (true)
{
cin >> x;
if (x == '1')
break;
}
ifstream ifile("TEST.txt");
if (!ifile)
{
cerr << "没有找到文件!请将输入放入 TEST.txt 中。\n";
continue;
}
string a, b;
ifile >> a >> b;
ifile.close();
if (!legal_string(a) || !legal_string(b))
{
cout << "#请输入合法的基因序列!\n";
Sleep(1000);
}
else
break;
}
}
char c;
while (true)
{
cout << "请选择比对规则:\n1.空缺优先(默认)\n2.错误优先\n3.没有优先\n";
cin >> c;
if (c != '1' && c != '2' && c != '3')
{
cout << "#请选择合法的选项!\n";
Sleep(1000);
}
else
break;
}
if (c == '2')
{
DIS_MATCH = -3;
INDEL = -1;
}
else if (c == '3')
{
DIS_MATCH = INDEL = -1;
}
}
int main()
{
while (true)
{
string a, b;
read(a, b);
ResUnit s = NeedlemanWunch(a, b);
if (choice2 == '1')
{
cout << s.res1 << endl;
cout << s.res2 << endl;
}
else
{
ofstream ofile{"ANS.txt", ios::out};
ofile << s.res1 << endl;
ofile << s.res2 << endl;
ofile.close();
}
Sleep(2000);
cout << "请选择:\n1.继续比对\n2.停止比对\n";
char c;
while (true)
{
cin >> c;
if (c != '1' && c != '2')
{
cout << "#请选择合法的选项!\n";
Sleep(1000);
}
else
break;
}
if (c == '2')
break;
}
return 0;
}
/*
"GGATCGA"
"GAATTCAGTTA"
*/
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