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<?xml version="1.0" encoding="utf-8"?>
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<ScrollView
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xmlns:android="http://schemas.android.com/apk/res/android"
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xmlns:app="http://schemas.android.com/apk/res-auto"
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xmlns:tools="http://schemas.android.com/tools"
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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>
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:orientation="vertical"
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android:background="@drawable/background"
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>
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:orientation="vertical">
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="189dp"
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android:background="#FFFFFF"
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android:orientation="vertical"
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android:layout_marginBottom="10dp">
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:layout_marginTop="20dp"
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android:orientation="horizontal">
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<ImageView
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android:id="@+id/detail_to"
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android:layout_width="47dp"
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android:layout_height="34dp"
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android:layout_gravity="center"
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android:src="@drawable/back" />
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<TextView
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android:id="@+id/textView30"
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android:layout_width="306dp"
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android:layout_height="match_parent"
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android:gravity="center"
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android:text="详情"
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android:textSize="19dp"
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android:textStyle="bold" />
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<ImageView
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android:id="@+id/detail_to_search"
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android:layout_width="66dp"
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android:layout_height="match_parent"
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app:srcCompat="@android:drawable/ic_menu_search" />
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</LinearLayout>
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<LinearLayout
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:padding="10dp">
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<TextView
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android:id="@+id/detail_theme"
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:text="儿童急性B淋巴细胞白血病,除了传统疗法还有哪些前沿治疗方法呢?"
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android:textSize="20dp" />
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</LinearLayout>
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<LinearLayout
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android:id="@+id/detail_to_answer"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:orientation="horizontal"
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android:padding="10dp">
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<TextView
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:text="查看全部回答"
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android:textColor="#66c18c"
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android:textSize="15dp" />
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<ImageView
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android:layout_width="24dp"
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android:layout_height="13dp"
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android:layout_gravity="center"
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android:src="@drawable/forwardgreen" />
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</LinearLayout>
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</LinearLayout>
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:orientation="vertical"
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android:layout_marginBottom="10dp"
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android:background="#FFFFFF">
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:orientation="vertical"
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android:padding="10dp">
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:orientation="horizontal">
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<ImageView
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android:id="@+id/imageView13"
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android:layout_width="104dp"
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android:layout_height="40dp"
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android:layout_weight="1"
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app:srcCompat="@drawable/person" />
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:layout_weight="1"
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android:orientation="vertical"
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android:layout_marginLeft="5dp">
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<TextView
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android:id="@+id/textView36"
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:text="LeudaemiaLikeMe"
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android:textSize="18dp"/>
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<TextView
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android:id="@+id/textView37"
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:text="管住嘴,迈开腿,多喝水" />
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</LinearLayout>
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</LinearLayout>
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<TextView
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android:id="@+id/textView38"
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:text=" 急性淋巴细胞白血病(ALL)是儿童最常见的恶性肿瘤,其中约85%为急性B淋巴细胞白血病(B-ALL)。随着联合化疗方案和支持治疗的进展,急性B淋巴细胞白血病患儿的生存率得到了显著提升,但复发难治性儿童急性淋巴细胞白血病的治疗仍是一大挑战。
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近年来,基因组分析技术的应用更加完善了儿童急性淋巴细胞白血病的分类,为更精确的分层及治疗提供了可能,部分靶向药物也已用于临床,为儿童急性淋巴细胞白血病提供新的治疗手段。此外,利用基因工程技术表达靶向嵌合抗原受体(CAR-T)细胞的过继免疫治疗在复发难治儿童急性B淋巴细胞白血病中同样取得了突破性进展。
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"
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android:layout_gravity="center"
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android:layout_margin="10dp"/>
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<TextView
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android:id="@+id/textView39"
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:text="儿童急性淋巴细胞白血病的治疗方案主要分为三个阶段。
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第一阶段:诱导缓解阶段
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目的在于杀伤血液和骨髓中的白血病细胞,短期内达到完全缓解(CR),包括临床症状消失、血象恢复正常、骨髓象恢复正常和原始细胞<5%。据研究统计,超过95%的患者在化疗后的4~6周达到CR。诱导期治疗主要方案有VDLP方案(长春新碱、柔红霉素、门冬酰胺酶和泼尼松) 或 VDLD方案(长春新碱、柔红霉素、门冬酰胺酶和地塞米松)。其中,门冬酰胺酶是治疗儿童急性淋巴细胞白血病的关键药物之一,通常需要较高剂量,其剂量与治疗疗效相关;相对于泼尼松,地塞米松则更有助于改善中枢神经系统(CNS)的症状。
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第二阶段:巩固治疗/强化治疗。
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旨在杀伤体内残留的或可能引起复发的白血病细胞。有研究显示,在诱导期治疗后和巩固治疗后均达到CR的儿童急性B淋巴细胞白血病患儿,5年的无病生存率(EFS)可达到92.3%。早期强化治疗可选择环磷酰胺+阿糖胞苷+6-MP(CAM方案)或CAML方案(+培门冬酶)。对于低、中危急性淋巴细胞白血病患儿,缓解后巩固治疗应用大剂量甲氨蝶呤+四氢叶酸钙+6-MP的治疗方案,高危患儿则需应用HR-1’、HR-2’、HR-3’方案。
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"
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android:layout_gravity="center"
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android:layout_margin="10dp"/>
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</LinearLayout>
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:orientation="horizontal"
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android:layout_margin="20dp">
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<LinearLayout
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android:id="@+id/detail_like"
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android:layout_width="70dp"
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android:layout_height="wrap_content"
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android:layout_marginRight="20dp"
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android:background="@drawable/search_background"
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android:gravity="center"
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android:orientation="horizontal">
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<ImageView
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android:layout_width="20dp"
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android:layout_height="20dp"
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app:srcCompat="@drawable/zan" />
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<TextView
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android:id="@+id/detail_like_num"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:layout_marginLeft="5dp"
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android:text="0" />
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<TextView
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android:id="@+id/textView41"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:layout_marginLeft="5dp"
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android:text="赞" />
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</LinearLayout>
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<LinearLayout
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android:id="@+id/detail_col"
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android:layout_width="77dp"
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android:layout_height="wrap_content"
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android:background="@drawable/search_background"
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android:gravity="center"
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android:orientation="horizontal">
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<ImageView
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android:id="@+id/imageView15"
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android:layout_width="20dp"
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android:layout_height="20dp"
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app:srcCompat="@drawable/collect" />
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<TextView
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android:id="@+id/detail_col_num"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:text="0" />
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<TextView
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android:id="@+id/textView43"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:text="收藏" />
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</LinearLayout>
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</LinearLayout>
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</LinearLayout>
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:orientation="vertical"
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android:background="#ffffff">
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="match_parent"
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android:orientation="horizontal"
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android:background="#FFFFFF"
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android:padding="20dp">
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<TextView
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android:id="@+id/textView45"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:text="评论"
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android:textSize="19dp"/>
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<TextView
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android:id="@+id/textView46"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:text="(0)"
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android:textSize="17dp" />
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</LinearLayout>
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<TextView
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android:id="@+id/textView47"
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android:layout_width="match_parent"
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android:layout_height="150dp"
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android:text="暂无评论"
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android:textSize="17dp"
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android:gravity="center"/>
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</LinearLayout>
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:orientation="vertical"
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android:background="#FFFFFF">
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<LinearLayout
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android:layout_width="match_parent"
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android:layout_height="wrap_content"
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android:background="@drawable/shape_round_corner"
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android:layout_margin="20dp">
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<ImageView
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android:id="@+id/imageView16"
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android:layout_width="20dp"
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android:layout_height="45dp"
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android:layout_marginRight="10dp"
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android:layout_marginLeft="20dp"
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app:srcCompat="@drawable/write" />
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<EditText
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android:id="@+id/editTextTextPersonName"
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android:layout_width="wrap_content"
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android:layout_height="wrap_content"
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android:ems="10"
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android:inputType="textPersonName"
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android:text="写评论"
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android:background="#F1EEEE"
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android:layout_marginTop="10dp"/>
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</LinearLayout>
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</LinearLayout>
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</LinearLayout>
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</LinearLayout>
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</ScrollView>
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